Using LASSO to estimate marker effects for Genomic Selection
نویسندگان
چکیده
منابع مشابه
Improved Lasso for genomic selection.
Empirical experience with genomic selection in dairy cattle suggests that the distribution of the effects of single nucleotide polymorphisms (SNPs) might be far from normality for some traits. An alternative, avoiding the use of arbitrary prior information, is the Bayesian Lasso (BL). Regular BL uses a common variance parameter for residual and SNP effects (BL1Var). We propose here a BL with di...
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Genomic selection (GS) using high-density single-nucleotide polymorphisms (SNPs) is promising to improve response to selection in populations that are under artificial selection. High-density SNP genotyping of all selection candidates each generation, however, may not be cost effective. Smaller panels with SNPs that show strong associations with phenotype can be used, but this may require separ...
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High-throughput gene expression technologies such as microarrays have been utilized in a variety of scientific applications. Most of the work has been done on assessing univariate associations between gene expression profiles with clinical outcome (variable selection) or on developing classification procedures with gene expression data (supervised learning). We consider a hybrid variable select...
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The success of genomic selection mainly depends on the extent of linkage disequilibrium (LD) between markers and quantitative trait loci (QTL), number of QTL and heritability (h2) of the traits. The extent of LD depends on the genetic structure of the population and marker density. This study was conducted to determine the effects of marker density, level of heritability, number of QTL, and to ...
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With the availability of high-density marker maps and cost-effective genotyping, genomic selection methods may provide faster genetic gain than can be achieved by current selection methods based on phenotypes and the pedigree. Here we investigate some of the factors driving the accuracy of genomic selection, namely marker density and marker type (i.e., microsatellite and SNP markers), and the u...
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ژورنال
عنوان ژورنال: Italian Journal of Animal Science
سال: 2009
ISSN: 1828-051X
DOI: 10.4081/ijas.2009.s2.168